Take part in a research project - Researching ways alcohol gets into your red blood cells


Testing for phosphatidylethanol (PEth) in red blood cells as a measure of past alcohol exposure.
You are invited to take part in this project. It is researching the way alcohol gets into your red blood cells, and after how long its presence can be detected. After drinking alcohol, a small amount of it gets into the red cells of blood. There, it is made into a substance named phosphatidylethanol (usually abbreviated to PEth). Once formed in the cell, PEth will remain for the life of the red cell and is not broken down. This research project aims to find out whether the amount of PEth depends on the amount of alcohol consumed and the time since consumption.
Most people are eligible to participate in this research project. The first thing to do is to read through the rest of this information. Then, call or email a study team member to organise a visit. The visit to meet with a study team member is so that you can learn about the research and what you need to do as a participant, and for the study team to learn a bit about you. Then, if you are sure that you are interested and the study team is sure you are eligible, you can choose how you want to participate. You can join in any of these 4 categories:
1.      You normally don’t drink any alcohol and can spare the time for the one visit to meet with a study team member and can give us one blood specimen;
or,
2.      You normally do drink alcohol, a are able to keep a diary of how much you drink for 1 week and can spare the time for the one visit to meet with a study team member and for a visit to a local PathWest collection centre for blood collection at the end of one week;
or,
3.      You normally do drink alcohol, are able to keep a diary of how much you drink for 3 weeks and can spare the time for the one visit to meet with a study team member and for a visit to a local PathWest collection centre for blood collection at the end of each of those three weeks;
or,
4.      You normally do drink alcohol, but want to stop alcohol for four weeks and you can spare the time for the one visit to meet with a study team member and for a visit to a local PathWest collection centre for blood collection at the end of each of those four weeks;
If you are interested, but want to learn more about the research and what you will have to do, please email us (daniel.white@health.wa.gov.au). We will send you a copy of the patient information document for this project. There are slight variations to the information, depending on which category you join, so please also let us know which categories interest you.
The project has been approved by Human Research Ethics Committee of Sir Charles Gairdner Healthcare Group. It is registered on the ANZ Clinical Trials Registry (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379329&isReview=true). The WHO Universal Trial Number is U1111-1248-6407.
 
Investigators:
Daniel White, Dr Sean O’Halloran; Prof David Joyce.
Clinical Pharmacology & Toxicology, PathWest Laboratory Medicine, QE II Medical Centre, Nedlands WA 6009.
Email: daniel.white@health.wa.gov.au