Molecular Pathology

The Molecular Anatomic Department was established in early 1990's and is located within the QEII network. The department provides a unified NATA accredited molecular diagnostic service for all public hospitals and several private laboratories in Perth.  The Molecular Pathology section provides patients and clinicians specialised, mainly DNA and RNA-based testing of tumours for purposes of accurate diagnosis, prognostication and prediction of response to tumour-specific therapies. Diagnostic modalities include the use of PCR, RT-PCR, capillary electrophoresis, Gene Scan analysis, DNA sequencing and High Resolution Melt curve analysis.
 
In lymphomas, the tests are used to establish cell lineage and B-cell or T-cell clonality, essential for accurate classification and treatment. Somatic mutation testing for a number of non-inherited cancers, such as EGFR testing for non-small cell lung cancer, are performed to determine response to tyrosine kinase inhibitor therapy. Similar testing for other genes is performed in the setting of metastatic malignant melanoma (BRAF and C-KIT mutations), gastrointestinal stromal tumours (C-KIT) and colorectal carcinoma (KRAS and BRAF mutations), results of which impact on the choice of therapy. Testing for microsatellite instability in colorectal carcinomas is also performed to identify patients who may have hereditary non-polyposis colorectal carcinoma, which has implications for further genetic testing in families. Moreover, the laboratory performs PCR-based chromosome translocation assays for accurate subtyping of lymphomas and diagnosis of sarcomas.  The Molecular Pathology laboratory has links with Genetic Services of WA, Molecular Genetics and also with the Cytogenetics Laboratory.
 
Pathologists with reporting responsibilities:
Dr Benhur Amanuel  (Head Pathologist)
Dr Dominic Spagnolo  
 
List of Molecular tests:
 
Laboratory staff:
Dr Jeremy Taylor
Dr Amerigo Carrello
Mr Tindaro Giardina
Ms Fabienne Grieu-Iacopetta
Dr Yordanos Tesfai
Ms Pei Ling Tan
 
Page last updated: 18 Mar 2015